Čes-slov Pediat 2025, 80(90):25-27 | DOI: 10.55095/CSPediatrie2025/045
Precocious puberty in a thirteen-month-old toddler
- 1 Dětské oddělení, Nemocnice České Budějovice a.s.
- 2 Klinika dětské hematologie a onkologie, 2. lékařská fakulta, Univerzita Karlova a Fakultní nemocnice v Motole, Praha
Precocious puberty is defined as the onset of puberty earlier than 2.5 SD of the mean population standard - breast enlargement in girls before 8 years of age or increasing testicular volume in boys before 9 years of age. We present case of a thirteen-month-old girl who suddenly developed
progressive breast enlargement and fine dark pubic hair. Laboratory results ruled out central precocious puberty. Due to elevated estradiol levels, peripheral precocious puberty (precocious pseudopuberty) was suspected. Imaging revealed a large mass originating from the right ovary. After referral to a higher-level facility, a laparotomic right-side
adnexectomy was performed. Histological examination confirmed a juvenile granulosa cell tumor. Following removal of the pathological source of endogenous hormones, the clinical signs of puberty stepwise resolved. The girl is currently asymptomatic and remains under specialist follow-up.
Keywords: precocious puberty, thelarche, estradiol, precocious pseudopuberty, juvenile granulosa cell tumor
Received: August 31, 2025; Revised: August 31, 2025; Accepted: September 17, 2025; Published: September 1, 2025 Show citation
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