Čes-slov Pediat 2026, 81(2):104-108 | DOI: 10.55095/CSPediatrie2026/013
A rare cause of cervical lymphadenopathy in childhood
- 1 Klinika dětí a dorostu, 3. lékařská fakulta, Univerzita Karlova, Fakultní nemocnice Královské Vinohrady, Praha
- 2 Ústav patologie, 3. lékařská fakulta, Univerzita Karlova, Fakultní nemocnice Královské Vinohrady, Praha
- 3 Otorinolaryngologická klinika, 3. lékařská fakulta, Univerzita Karlova, Fakultní nemocnice Královské Vinohrady, Praha
- 4 Klinika radiologie a nukleární medicíny, 3. lékařská fakulta, Univerzita Karlova, Fakultní nemocnice Královské Vinohrady, Praha
- 5 Klinika dětské hematologie a onkologie, 2. lékařská fakulta, Univerzita Karlova, Fakultní nemocnice Motol, Praha
The differential diagnosis of cervical lymphadenopathy in children is broad, with infectious and benign causes accounting for the majority of cases. This makes it particularly challenging to recognize more serious or rare conditions. Kikuchi-Fujimoto disease, also known as histiocytic necrotizing lymphadenitis, is a rare, benign, and self-limiting disorder first described in the 1970s. It predominantly affects young adults and often mimics infectious or autoimmune conditions. Due to its rarity, Kikuchi-Fujimoto disease poses a diagnostic challenge in the paediatric population. In this case report, we present the clinical course, diagnostic process and therapeutic considerations in a paediatric patient diagnosed with this uncommon condition.
Keywords: Kikuchi-Fujimoto disease, histiocytic necrotizing lymphadenitis, differential diagnosis, multidisciplinary approach
Accepted: February 5, 2026; Published: March 1, 2026 Show citation
References
- Weinstock M, Patel N, Smith L. Pediatric cervical lymphadenopathy. Pediatr Rev 2018; 9(39): 433-443.
Go to original source... 
Go to PubMed... - David J, Votava F, et al. Diferenciální diagnostika v pediatrické praxi. Praha: Grada 2025.
- Abdu A, Pajkrt D, Bijker EM. Kikuchi disease in children: case report and review of the literature. Pediatr Infect Dis J 2022; 41(3): 199-204. Go to original source... Go to PubMed...
- Choi S, Choi HS, Ryu YJ, et al. Characterization of Kikuchi-Fujimoto disease in children and risk factors associated with its course. J Pediatr 2023; 260: 113515. Go to original source... Go to PubMed...
- Mathew LM, Kapila R, Schwartz RA. Kikuchi-Fujimoto disease: a diagnostic dilemma. Int J Dermatol 2016; 55(10): 1069-75. Go to original source... Go to PubMed...
- Liu B, Sun Y, Shi WY, et al. Clinical characteristics and risk factors for recurrence of Kikuchi-Fujimoto disease in children: a case-control study. BMC Pediatr 2025; 25(1): 485. Go to original source... Go to PubMed...
- Kim TY, Ha KS, Kim Y, et al. Characteristics of Kikuchi-Fujimoto disease in children compared with adults. Eur J Pediatr 2014; 173(1): 111-116. Go to original source... Go to PubMed...
- Lin HC, Su CY, Huang CC, et al. Kikuchi's disease: a review and analysis of 61 cases. Otolaryngol Head Neck Surg 2003; 128: 650-653. Go to original source...
- Park JE, Jung HJ, Kim C-H, et al. Kikuchi disease in Korean children: clinical features and disease courses. Blood 2007; 110: 2285. Go to original source...
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